Bladder Melanosis A Rare Cystoscopic Finding
Main Article Content
Abstract
This case report describes a rare cystoscopic finding in an octogenarian, presenting initially with nonspecific lower urinary tract symptoms. Physical examination did not reveal any abnormal skin or mucoepi-dermoid pigmentation. Routine ultrasound identified cystic changes in the bladder prompting cystoscopic investigation. Flexible cystoscopy identified melanin deposits within the bladder mucosa, and biopsy subsequently confirmed a diagnosis of bladder melanosis. The authors of this report wish to add to the available literature on this extremely rare finding in the hope a more robust evidence base would allow a protocol to be established for follow-up. The ultrasound findings reported in this study have not been previously
reported and may benefit future guidelines on diagnosis.
Downloads
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright of articles published in all DPG titles is retained by the author(s). The author(s) grants DPG the rights to publish the article and identify itself as the original publisher. The author grants DPG exclusive commercial rights to the article. The author grants any party the rights to use the article freely for non-commercial purposes provided that the original work is properly cited.
References
2. Jin B, Zaidi SY, Hollowell M, Hollowell C, Saleh H. A unique case of urinary bladder simple melanosis: A case report and review of the literature. Diagn Pathol. 2009;4:24. doi:10.1186/1746-1596-4-24
3. Alroy J, Ucci AA, Heaney JA, Mitcheson HD, Gavris VE, Woods W. Multifocal pigmentation of prostatic and bladder urothelium. J Urol. 1986;136(1):96–7. doi:10.1016/s0022-5347(17) 44743-4
4. Lopategui DM, Griffith RC, Santos Cortes J. Melanosis of the bladder: A rare diagnosis. Urol Case Rep. 2020;33:101283. doi: 10.1016/j.eucr.2020.101283
5. Sawalem K, Mehdi MZ, Ansari AH, Ramadan A. Melanosis of bladder: A rare entity. Urol Case Rep. 2019;27:100916. doi:10.1016/j.eucr.2019.100916
6. Sen Gupta R, Seidl E, Oberpenning F. An unusual and rare case of urinary bladder melanosis. J Endourol. 2010;24(4):525–6. doi:10.1089/end.2009.0603
7. Bumbu GA, Berechet MC, Pop OL, Nacer K, Bumbu G, Maghiar OA, et al. Primary malignant melanoma of the bladder—Case report and literature overview. Rom J Morphol Embryol. 2019;60(1):287–92.
8. Stein BS, Kendall AR. Malignant melanoma of the genitourinary tract. J Urol. 1984;132(5):859–68. doi: 10.1016/s0022-5347(17)49927-7
9. Bates AW, Baithun SI. Secondary neoplasms of the bladder are histological mimics of nontransitional cell primary tumours: Clinicopathological and histological features of 282 cases. Histopathology. 2000;36(1):32–40. doi: 10.1046/j.1365-2559.2000.00797.x
10. Barillaro F, Camilli M, Dessanti P, Gorji N, Chiesa F, Villa A, et al. Primary melanoma of the bladder: Case report and review of the literature. Arch Ital Urol Androl. 2018;90(3):224–6. doi:10.4081/aiua.2018.3.224
11. Venyo AK-G. Melanoma of the urinary bladder: A review of the literature. Surgery research and practice. 2014;2014:605802. doi:10.1155/2014/605802
12. Lee CS, Komenaka IK, Hurst-Wicker KS, Deraffele G, Mitcham J, Kaufman HL. Management of metastatic malignant melanoma of the bladder. Urology. 2003;62(2):351. doi:10.1016/s0090-4295(03)00354-6
13. Atkins MB, Lotze MT, Dutcher JP, Fisher RI, Weiss G, Margolin K, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993. J Clin Oncol. 1999;17(7):2105–16. doi:10.1200/JCO.1999.17.7.2105
14. Rubio G, Gomez G, Valero R, Salguero S, Pineda R. Primary melanoma of the bladder at puerperium: Case report. Int Arch Urol Complic. 2020;6:073.
15. Quaquarini E, Saltalamacchia G, Tresoldi M, Schmid M, Villani L, Bernardo A, et al. Primary melanoma of the bladder: A case report and review of the literature. Eur Rev Med Pharmacol Sci. 2021;25(16):5122–8. doi:10.26355/eurrev_ 202108_26523
16. Di Fiore F, Pone D, Domizio S, Uricchio F, Tufano A, Testa G, et al. Melanosis of the bladder: A rare endoscopic and histopathological finding. Urol Int. 2007;78(2):185–7. doi:10.1159/000098082
17. Atieh M, McIntire PJ, Kilic I, Picken MM, Flanigan RC, Barkan GA, et al. Lipofuscin pigmentation (so called “melanosis”) of the bladder. Diagn Cytopathol. 2019;47(9):968–71. doi:10.1002/dc.24204
18. Yau SE, Singer EJ, Sun Y, Johnson MH. Bladder melanosis with concurrent urothelial carcinoma. Urol Case Rep. 2017;15:30–2. doi:10.1016/j.eucr.2017.09.001
19. Harikrishnan JA, Chilka S, Jain S. Urinary tract transitional cell carcinoma and melanosis of the bladder: A case report and review of the literature. Ann R Coll Surg Engl. 2012;94(4):e152–4. doi:10.1308/003588412X13171221589135
20. Sanborn SL, MacLennan G, Cooney MM, Zhou M, Ponsky LE. High-grade transitional cell carcinoma and melanosis of urinary bladder: Case report and review of the literature. Urology. 2009;73(4):928. e13–5. doi:10.1016/j.urology.2008.05.039
21. Mera Z, Patel S, Qassid O, England R. Unusual case of simple urinary bladder melanosis with complete resolution. BMJ Case Rep. 2018;2018: bcr2018224361. doi:10.1136/bcr-2018-224361
22. Rossen K, Petersen MM. Simple melanosis of the bladder. J Urol. 1999;161(5):1564.
23. Talmon GA, Khan AU, Koerber RK, Johansson SL. Simple melanosis of the bladder: A rare entity. Int J Surg Pathol. 2010;18(6):547–9. doi:10.1177/1066896909352863
24. Engelhardt PF, Hohlbrugger G, Riedl CR. [Melanosis of the urinary bladder—A case report with 10 years of follow-up and review of literature]. Aktuelle Urol. 2006;37(3):222–4. doi:10.1055/s-2005-919095